Fig. 3. A glance into the process of heart progenitor cell lineages development (From Laugwitz et al., 2008) [54] . The expression of lineage markers shown is based on the following studies: Kattman et al., 2006, Moretti et al., 2006 and Wu et al., 2006. The expression of Nkx2.5 in the precardiac mesoderm controls both endothelial and hematopoietic lineages development from the myocardial lineage [46, 54]. Abbreviations: Bry, brachyury T; MLC2a, atrial myosin light chain 2; MLC2v, ventricular myosin light chain 2; cTNT, cardiac troponin T; HCN4, hyperpolarization-activated cation channel 4; SM-MHC, smooth muscle myosin heavy chain; VE-Cadh, VE-Cadherin.